Tag: sarcoidosis

Antiphospholipid Antibodies: Discussion

Therefore, the presence of immune type aPL is thought to be responsible for the occurrence of thrombotic complications because foGPI is a well-known plasma protein with anticoagulant activity. The enzyme-linked immunosorbent assay method we applied in the present study for the detection of aPL can detect these two types of aPL, but cannot distinguish them….

Continue Reading →

Antiphospholipid Antibodies: Analysis

There were 23 cases in which abnormal chest x-ray film findings disappeared within 2 years, but 23 cases in which these findings persisted for over 2 years. The aPL frequency was 13 percent (3 of 23) in the former group and 65 percent (15 of 23) in the latter. Nine cases not included in this…

Continue Reading →

Antiphospholipid Antibodies: Results

Frequency of Antiphospholipid Antibodies Twenty-one (9 male and 12 female) of 55 (38 percent) cases of sarcoidosis had aPL (IgG or IgM aPL or both). In contrast, only 5 (7 percent) of 70 cases in the control group were positive for aPL. The presence of aPL was significantly higher (p<0.01) in patients with sarcoidosis (Fig…

Continue Reading →

Antiphospholipid Antibodies: Methods

The IgG and IgM antibodies against each phospholipid were measured by an enzyme-linked immunosorbent assay method. Microtiter plates were coated with each type of phospholipid and diluted with methanol to 50 Mg/ml. After drying at 50°C for 30 min and washing 3 times in 0.01 mol/L phosphate-buffered saline (PBS), 50 Mg/ml of 10 percent bovine…

Continue Reading →

Antiphospholipid Antibodies: Materials

Sarcoidosis is a systemic disease of unknown cause characterized by the presence of non-caseating epithelioid cell granulomas in affected organs and shows a variety of clinical courses. It is well-known that patients with sarcoidosis have humoral immunologic abnormalities. Canadian helth& care mall Increases in serum immunoglobulin and complications of autoimmune diseases also have been reported….

Continue Reading →

HLA Class I, II, and III Polymorphism in Italian Patients With Sarcoidosis: Conclusion

With regard to the association of HLA-radiologic stage of sarcoidosis, the most important deviations have been found in the group of patients in stage I (Table 3). HLA-B8,DR3 shows a higher frequency in stage I with respect to healthy control subjects and patients with stage III sarcoid. We are reminded that HLA-B8 seems to be…

Continue Reading →

HLA Class I, II, and III Polymorphism in Italian Patients With Sarcoidosis: Discussion

Though available data are too scant to draw a worldwide map of HLA-sarcoidosis associations, some results of our investigation seem to be in agreement with literature findings. We confirm suggestions of European investigators about MHC association witH sarcoidosis: HLA-B8 appears to be positively related to the disease in whites (Table 2). These data could not…

Continue Reading →

HLA Class I, II, and III Polymorphism in Italian Patients With Sarcoidosis: Results

Characteristics of Patients with Sarcoid Data are described in Table 1. In our series, the female:male ratio was 1.48:1. The sample study enrolled a large majority of nonsmokers (69.15 percent). Only 37 patients (34.57 percent) were asymptomatic (chest radiographic abnormalities noticed during periodic screening), whereas most of patients (65.42 percent) had symptoms (dyspnea, fever, erythema…

Continue Reading →

HLA Class I, II, and III Polymorphism in Italian Patients With Sarcoidosis: Methods

Subjects We studied 107 patients (64 female and 43 male) with newly recognized, biopsy specimen-proven sarcoidosis admitted to our departments (Pavia and Padova) from May 1988 to April 1991. The mean age at the onset of the disease was 36.08 years (39.3 years for female subjects and 31.13 years for male subjects), ranging from 18…

Continue Reading →

HLA Class I, II, and III Polymorphism in Italian Patients With Sarcoidosis

Sarcoidosis is a multisystem granulomatous disorder characterized by an accumulation of immunocompetent cells at sites of disease activity. Though the etiology is unknown, both prevalence of sarcoidosis in different ethnic groups and familial occurrence of the disease strongly put forward the hypothesis of a possible genetic predisposition. Frequencies of human leukocyte antigens (HLA) coded by…

Continue Reading →