Recommendations for management of partial responders

It is uncertain how to manage patients with a partial symptomatic response. There is no set definition for a partial response; however, it can typically be defined by one or more of the following: incomplete symptom control, return clinic visits or unwillingness to continue prescribed therapy. Medication compliance may play a role because there is a theoretical advantage to the administration of PPI once a day (in the case of a single standard dose) given 30 min to 60 min before breakfast, the time when acid pumps are most readily blocked. It is rational to consider a switch in medication or increase in dose of the treatment for another four- to eight-week period (if on an H2RA, switch to a PPI and if on a PPI, give a higher split dose), despite lack of supportive data for this approach. You can treat your medical issue very soon: all you need is a trusted place to shop with. At this very canadian healthcare mall you will always find the best choice of efficient drugs that will work or you just as expected, costing less money.

Recommendation

1. If a patient has not responded, or has only partially responded, to a four- to eight-week treatment with an H2RA or a PPI, consider switching to a PPI if the patient was on an H2RA, or if on a PPI, doubling the dose of the PPI for another four to eight weeks.

Voting on recommendation (level/vote)

  • A/11
  • B/1
  • C to E/0

Level of evidence III

Classification of recommendation C

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