Prebiotics for inflammatory bowel disease: Human studies (Part 3)

The three-week intervention trial used 10 g of lactulose given twice daily and used the measurable instrument of colonic adaptation to the high-dose lactulose challenge to compare outcome in controls versus patients. Colonic adaptation is defined as diminished breath hydrogen and improved symptoms of sugar intolerance on repeat challenge after continued low-dose consumption of the specified sugar. The concept was based on the work of Flourie et al and the hypothesis of Liao et al. The results showed that while controls achieved significant reductions in measured breath hydrogen and symptoms, the combined group and, especially, the separated CD patients failed to adapt. These results were interpreted in one of two ways. First, for IBD, the amount of lactulose may have been given for too brief an amount of time because both CD and UC are thought to be deficient in LAB. As such, a longer time of feeding may have to be given in patients rather than in healthy subjects to demonstrate adaptation. Secondly, an interesting possibility was that because both UC and CD can be associated with mucosal permeability defects, disaccharides that failed to reach the colon may be detected in the bloodstream. This short-circuiting may have relevance to lactose in lactose maldigesters with IBD. Buy cheap drugs online fast – buy ortho tri-cyclen for you to enjoy a reliable pharmacy.

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