Prebiotics for inflammatory bowel disease: Human studies (Part 2)

patients treated with GBFThere are three published open-label studies comprising a total of 49 patients treated with GBF for mild to moderately active UC in Japan. The first pilot study by Mitsuyama et al showed clinical improvement with GBF 30 g/day for four weeks. A follow-up study also for four weeks with 20 g to 30 g GBF per day using slightly larger numbers also showed clinical improvement and confirmed that bifidobacteria and eubacteria were increased in the stool. A more recent study by the same group extended treatment for 24 weeks and again showed clinical improvement. In all of these studies, patients were continued on standard 5-ASA or corticosteroid therapy and these were continued throughout the observation period.

There is only one study to date which attempts to address the possible impact of prebiotics as therapy for CD. The study involved nasogastric feeding of 10 children with active CD for a period of six weeks using a whey protein peptide-based formula containing a mixture of FOS and inulin. Results showed the children gained weight and the pediatric CD activity index improved. Unfortunately, the role of added pre-biotics is not clear because similar results can be obtained without their addition. Shop online with the best pharmacy that will ensure high quality of your medications and will offer cheapest birth control for women with no rx required any time you need this or any other one for your medical problem.

A second study is somewhat different. A small study was published comparing 15 healthy controls with 20 patients with colonic IBD (9 UC, 9 CD, and two indeterminate colitis).

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