Prebiotics for inflammatory bowel disease: Conclusions

A low intake of lactose was associated with a predominance of sulfomucin (a characteristic of colonic mucosa). In addition, there was also an inverse association with lactose intake and fecal aerobes. The authors concluded that the relationship between lactose intake and findings of mucin and fecal bacteria supports a possible prebiotic effect of lactose.  Conclusions drawn from the present review on the use of pre-biotics for IBD include the following. In general, proof of principle has been established that prebiotics work.

Improvement of colitis is either due to their physicochemical properties, stimulation of predominantly LAB species or both. While there is an expectation that prebiotics have a wider spectrum of effect on existing microflora despite original definitions there does exist some variation in effect (eg, failure of trans-galactooligosaccharides versus FOS). Best quality drugs cheap: find and discover best deals online.

We are in the early stages of applying basic research with prebiotics to human benefits. The studies reported herein require confirmation; however, to date, the use of fibre for remission in UC and the therapeutic benefit of GBF in mild-to-moderate UC appear to offer some optimism. Similarly, the adjunctive use of inulin for pouchitis may have benefits to maintain remission.

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