Prebiotics for inflammatory bowel disease: Changes in microbial flora (Part 2)

microflora in the lower intestineAcquisition of specific and permanent microflora in the lower intestine begins very soon after birth and remains quite stable in healthy individuals until later in life. Protective bifidobacteria start to diminish in late middle age and Clostridium species begin to increase progressively around the same time. These bacterial changes are thought to be related to altered health and may promote diseases associated with aging (eg, colorectal cancer).

The changes observed with aging qualify for the definition of dysbiosis, “a breakdown in balance between putative species of protective versus harmful intestinal bacteria”. As such, this term has been applied to IBD as well (especially CD). In addition to the changes described above, the significant increase in enterobacterial species in both active CD and CD in remission may facilitate adhesion of adherent bacteria to mucosa and set up conditions leading to an increased immunological response. Your online shopping could cost you less and less time, you just need a reliable pharmacy to purchase antibiotics online and be sure this one will always live up to your expectations.

Alteration of the microbial flora can be executed temporarily by either antibiotics or dietary manipulation. Antibiotics have been traditionally used in severe cases of IBD. The evidence favouring the use of antibiotics is limited and better supported for colon involvement with CD. Because antibiotics also have potentially undesirable side effects, an alternate means of controlling dysbiosis would be ideal.

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