Prebiotics for inflammatory bowel disease: Animal studies (Part 2)

rats treated with GBFIn dextran sulfate sodium-challenged rats treated with GBF, both bifidobacteria and eubacteria were measurably increased and the total number of aerobes and bac-teroides were decreased. In addition to these effects, the glutamine-containing portion of GBF may also exert independent effects. Rats exposed to glutamine alone, before another agent (trinitrobenzene sulfonic acid [TNBS]), showed resistance to inflammation.

Prebiotics, much like individual species of probiotics, may exert specific effects on the type of colitis induced. Using the TNBS (enema) model of Crohn’s colitis, Holma et al were unable to show prevention of colonic damage despite elevation of bifidobacteria using transgalactooligosaccharides (a manufactured prebiotic produced from lactose). The authors argued that perhaps TNBS was too severe a model of colitis. Nevertheless, Cherbut et al using the same model showed that intragastric installation of FOS ameliorated colitis. Intracolonic installation of SCFAs at less than pharmacological doses required the addition of LAB. The authors suggested that in this experiment FOS exerted benefits by supporting the growth of LAB in improving colitis. You finally have a choice and can find yourself a perfectly reliable pharmacy to shop with for best medications available: buy cipro and see how quick and easy it could be to spend less money.

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