Postpericardiotomy and Postmyocardial Infarction Syndrome (13)

Postpericardiotomy and Postmyocardial Infarction Syndrome (13)The postcardiotomy syndrome (PPS) and its possible relationship to a hypersensitivity reaction was first described in 1961. The authors described a delayed pericardial reaction following 30 of 100 consecutive congenital heart operations in which the pericardium was widely incised, and they believed that the syndrome probably represented a hypersensitivity response to blood in the pericardial sac that had already undergone traumatic pericarditis. birth control yasmin
In 1974, a similar sampling with a comparable incidence (30 percent) of the PPS in children was studied measuring immunofluorescent heart-reactive antibody titers. A close correlation of high heart antibody titers and the PPS was demonstrated. Significant titers were not seen in patients without the ppS 12 jije authors hypothesized that antibody appeared in the immunologically susceptible host in response to epicardial injury incurred in the pericardiotomy and to blood in the pericardial sac. Interestingly, they speculated that the pleural reaction in these cases was a “neighborhood” response by the adjacent tissue. In 1981, similar studies were done in adults who underwent heart surgery. Most of these were bypass cases, and 23 of 142 developed’the PPS (17.6 percent). High titers of heart-reactive antibodies were found in all the patients thought to have the PPS. In addition, antiviral antibody titers were obtained to eight common viruses with a rise in titer in 68 percent of the PPS cases but in only 5 percent of those without the syndrome. The authors suggested the autoimmune response noted may have been triggered by a viral illness.

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