Outcomes of a Web-Based Patient Education Program for Asthmatic Children and Adolescents: Results

Outcomes of a Web-Based Patient Education Program for Asthmatic Children and Adolescents: ResultsResults are presented as severity-adjusted mean scores for the population per peer protocol (PPP), for subgroups, and for the intention-to-treat (ITT) population. As a standard in health economic evaluations, one-way sensitivity analyses were performed in order to test for the influence of variations in drug therapy adherence, outpatient visit costs, and intervention costs on the benefit-cost ratio. The data were analyzed using statistical software (Version 10.0; SPSS; Chicago, IL).
The original study sample consisted of 358 patients. A further 80 patients were interested in participating but could not be included as they did not meet inclusion criteria. Complete medical resource use data at all follow-up visits were available for 178 patients (49.7%) who were defined as PPP (Table 2). Medical resource use data of 56 study completers were insufficient for analysis (15.6%).
Reasons for study discontinuation (n = 124; 34.6%) were as follows: relocation of patients (n = 6), withdrawal of caregiver consent (n = 6), nonattendance of scheduled follow-up visits (n = 11), no returning of mail questionnaires (n = 41), and relocation of personnel in two study centers (n = 19). Reasons for dropouts were not documented in 41 cases. Patient characteristics are summarized in Table 3. website

Compared to both intervention groups, significantly more patients in the CG were male. In the IEP group, significantly more patients presented with allergies when compared to the SPMP group.
Although not statistically significant (p = 0.17), the proportion of patients with moderate or severe asthma in the IEP group (65.9%, n = 29) tended to be higher than in the SPMP group (44.2%; n = 38) and in the CG (39.6%; n = 19). At baseline, a total of 116 patients (65.2%) received inhaled corticosteroids, with no statistically significant differences between groups.

Table 2—Number of Patients Per Study Group and Eligibility for Analysis

Variables CG Intervention Groups Total
SPMP SPMP Plus IEP
ITT population* 85 127 146 358
IEP not used (n = 66) 66t 66
Study discontinuation 17 80 27 124
Resource-use data incomplete 20 27 9 56
PPPJ 48 86 44 178

Table 3—Demographic and Clinical Variables by Study Group

Variables CG (n = 48) SPMP (n = 86) SPMP Plus IEP (n = 44)
Age, yr 11.5 ± 2.9 11.1 ± 2.4 11.0 ± 2.2
Male gender 38 (79.2)tj 47 (54.7) 29 (65.9)
Height, cm 152.1 ± 19.1 150.1 ± 15.8 148.4 ± 13.9
Weight, kg 51.0 ± 29.5 45.6 ± 17.4 43.8 ± 15.2
Degree of asthma severity
Mild intermittent 7(14.6) 12 (14.0) 3 (6.8)
Mild persistent 20 (41.7) 36(41.9) 12 (27.3)
Moderate persistent 19 (39.6) 37 (43.0) 27 (61.4)
Severe persistent 1(1.2) 2 (4.5)
Not answered 2 (4.2)
Asthma diagnosed since, yr 5.9 ± 4.2 5.5 ± 3.5 6.3 ± 3.6
Any allergy 43 (89.6) 68 (79.1) 43 (97.7)
Seasonal allergic rhinitis 20 (41.7) 41 (47.6) 24 (54.5)
Atopic asthma 13(27.1) 25 (29.1) 11 (25.0)
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