Inhaled Albuterol and Oral Prednisone Therapy in Hospitalized Adult Asthmatics: Results (3)

Inhaled Albuterol and Oral Prednisone Therapy in Hospitalized Adult Asthmatics: Results (3)Summarized in Table 2 are the spirometric values for all 39 patients in both groups at admission and discharge. Table 3 shows the comparison of subjective patient rating, and Table 4 the duration of hospitalization. Among the more severely ill patients whose FEVi was ^35 percent predicted on admission to the hospital, analysis revealed no difference in any response parameter between the placebo group (n = 7) and aminophylline group (n = 11). The mean serum theophylline concentration was 13.6 ±4.1 |xg/ml during the course of hospitalization for the aminophylline group. Analysis of patients whose serum theophylline concentration was ^15 |xg/ml (n = 9) vs <15 |xg/ml (n = 12) revealed no significant difference in any response parameter. Cheap Diskus Advair

Among patients who completed the study, two patients in the placebo group and two patients ill the aminophylline group were given nebulized glycopyrrolate during the course of hospitalization. Five patients in the placebo group and three patients in the aminophylline group were given extra doses of nebulized albuterol during the hospital stay. Based on daily queries for specific side effects of nausea, vomiting, palpitations, tremor, or nervousness, eight patients in the aminophylline group had side effects (slight nervousness and tremor, five; palpitations, three; tremor only, two) and seven patients in the placebo group had side effects (slight nervousness, two; tremor, one; palpitations, two; nausea, two). These side effects were usually reported only on the first hospital day. There were no complications in the 39 patients who completed the study.

Table 2—Comparison of Spirometric Values at Admission and at Discharge

FVC % Predicted FEV,% Predicted FEF25-75 % Predicted
Admission (N = 39)
Placebo 63.0±3.9 41.5±2.9 18.4± 1.7
Aminophylline 64.7±3.8 34.7±2.3 15.0±1.6
Discharge (N = 39)
Placebo 90.5±2.9 70.4 ±2.9 39.1 ±2.9
Aminophylline 89.0 ±3.0 63.7±2.8 33.6±3.2

Table 3—Comparison of Subjective Rating

Subjective Patient Rating Placebo Aminophylline P n
Day 1 4.18 ±.05 4.47 ±.03 0.17 39
Day 2 4.63±0.4 4.78 ±.03 0.50 29
Day 3 4.63 ±.09 4.85±.05 0.55 15

Table 4—Duration of Hospitalization

Placebo Aminophylline P n
Hospital stay 1.95 ±.19 1.78 ±.16 .51 39
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