Donor Selection for Single and Double Lung Transplantation

Donor Selection for Single and Double Lung TransplantationSingle lung transplantation (SLT) and double lung transplantation (DLT) have proved successful in patients with end-stage pulmonary diseases. Both SLT and DLT lead to significant improvement in standard parameters of pulmonary function. However, factors that influence or determine posttransplantation pulmonary function have not been carefully studied.
Criteria for donor selection for lung transplantation have been proposed, but these have usually focused on ensuring a viable, infection-free donor lung. Donor-recipient size matching has generally been accomplished by anthropometry with an emphasis on comparison of thoracic dimensions. However, the normal thoracic volume of the recipient is markedly altered by the underlying lung disease, and a suitable chest size match may be difficult to estimate by this method.
In this study the relationship of the posttransplantation vital capacity of SLT and DLT recipients (posttx VCr) to their own predicted normal vital capacity (pred VCr) and to their donors predicted normal vital capacity (pred VCD) was studied. The results provide some insights into donor-recipient factors that influence the restoration of static lung function after SLT and DLT.

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