Category Archives: Sarcoidosis

HLA Class I, II, and III Polymorphism in Italian Patients With Sarcoidosis: Conclusion

HLA Class I, II, and III Polymorphism in Italian Patients With Sarcoidosis: ConclusionWith regard to the association of HLA-radiologic stage of sarcoidosis, the most important deviations have been found in the group of patients in stage I (Table 3). HLA-B8,DR3 shows a higher frequency in stage I with respect to healthy control subjects and patients with stage III sarcoid. We are reminded that HLA-B8 seems to be associated with a good prognosis, and it could not be a simple coincidence if people possessing this allele belong to the radiologic stage I, in which a good outcome is more frequent with respect to other radiologic stages.
Concerning sex of patients and extent of the disease, we noticed several interesting associations, but none of these reached the significance when the p value was corrected for the number of antigens tested. cialis professional 20 mg

Continue reading

HLA Class I, II, and III Polymorphism in Italian Patients With Sarcoidosis: Discussion

Though available data are too scant to draw a worldwide map of HLA-sarcoidosis associations, some results of our investigation seem to be in agreement with literature findings. We confirm suggestions of European investigators about MHC association witH sarcoidosis: HLA-B8 appears to be positively related to the disease in whites (Table 2). These data could not be confirmed in West Indian or Japanese patients, the latter belonging to a population where B8 is a very rare antigen. It is known that HLA-B8,DR3 antigens may be linked to disorders with an immunologic basis and that HLA-B8,DR3 positive individuals may undergo the development of diseases with an autoimmune component. Both these observations fit the current concepts on the pathogenesis of sarcoidosis. We cannot draw any conclusion in our series about a possible association of HLAr prognosis, as others have previously published, since at the moment of the preparation of this manuscript, most of our patients have not reached a sufficient follow-up period. canadianfamilypharmacy

Continue reading

HLA Class I, II, and III Polymorphism in Italian Patients With Sarcoidosis: Results

HLA Class I, II, and III Polymorphism in Italian Patients With Sarcoidosis: ResultsCharacteristics of Patients with Sarcoid
Data are described in Table 1. In our series, the female:male ratio was 1.48:1. The sample study enrolled a large majority of nonsmokers (69.15 percent). Only 37 patients (34.57 percent) were asymptomatic (chest radiographic abnormalities noticed during periodic screening), whereas most of patients (65.42 percent) had symptoms (dyspnea, fever, erythema nodosum, arthralgia, cough, chest pain, or ophthalmic symptoms). Radiologic stage II assembled 40 patients (37.38 percent), whereas 38 patients (35.51 percent) were assigned to stage I, and 25 (23.36 percent) were assigned to stage III. Finally, 38 patients (35.51 percent) had one or more extrapulmonary localizations of the disease.
Continue reading

HLA Class I, II, and III Polymorphism in Italian Patients With Sarcoidosis: Methods

Subjects
We studied 107 patients (64 female and 43 male) with newly recognized, biopsy specimen-proven sarcoidosis admitted to our departments (Pavia and Padova) from May 1988 to April 1991. The mean age at the onset of the disease was 36.08 years (39.3 years for female subjects and 31.13 years for male subjects), ranging from 18 to 64 years. As controls, the HLA phenotype frequencies obtained in 510 healthy individuals from continental Italy and reported in the Data Book Addendum—Anthropological Analysis, from the 11th Histocompatibility Workshop book were employed. BF allotyping was performed in 382, and C4A and C4B allotyping in 370 healthy northern Italian control subjects.
Assessment of Sarcoidosis
Patients with sarcoid were assessed by bronchoalveolar lavage, Ga lung scanning with computer-assisted score expressed Ga uptake, pulmonary function tests, and serum angiotensin-converting enzyme activity. The chest radiograph was evaluated according to De Remee and patients were assigned to stage I (bilateral hilar lymphoadenopathy [BHL], II (BHL and diffuse pulmonary involvement), or III (diffuse pulmonary involvement only). Typing for HLA class I and II antigens was performed in all patients with a set of sera, whose reliability was proven during the Tenth International Histocompatibility Workshop, using the National Institutes of Health microlymphocytotoxicity method. The technique of resetting with sheep erythrocytes (SRBC) was employed to remove T cells and obtain enriched Ð’-cell suspensions, as previously described.
Continue reading

HLA Class I, II, and III Polymorphism in Italian Patients With Sarcoidosis

HLA Class I, II, and III Polymorphism in Italian Patients With SarcoidosisSarcoidosis is a multisystem granulomatous disorder characterized by an accumulation of immunocompetent cells at sites of disease activity. Though the etiology is unknown, both prevalence of sarcoidosis in different ethnic groups and familial occurrence of the disease strongly put forward the hypothesis of a possible genetic predisposition.
Frequencies of human leukocyte antigens (HLA) coded by genes of the HLA region in patients with sarcoidosis have been studied by many investigators in order to understand the role of immunogenetic factors in the pathogenesis of this disease. Despite the relatively large body of published articles, a final conclusion on the association of sarcoidosis and HLA has not been reached. Conflicting results were achieved when different ethnic groups were considered, so that, for instance, from pooled data an association between HLA and sarcoidosis in Caucasians has been denied. When another ethnic group or narrower caucasian groups were considered, the existence of association between sarcoidosis and certain HLA alleles, especially B8 in Caucasians, has been recognized. This implies the presence of a putative sarcoidosis-susceptibility gene within or linked to the HLA region.
Continue reading