Autoradiographic Localization and Characterization of Angiotensin II Receptors: RESULTS(3)

Angiotensin II Receptor Densities

The amount of Ang II receptor, related to the protein in cell membrane fractions from placentae and fetal membranes of various stages of gestation, is given as fmol/mg membrane protein and is shown in Table 2. The amount was lower in the placentome than in the intercotyledonary allantochorionic membrane (p < 0.001) and the allantoamnionic membrane (p < 0.001). It changed during gestation in the placentome (p < 0.005) and the intercotyledonary membrane (p < 0.02), but it did not change in the allan-toamnionic membrane. ventolin inhalers

The lowest values were found in the third part of gestation in the placentome and intercotyle-donary membrane. The amount of Ang II receptor related to the wet tissue weight (fmol/g wet tissue) was calculated by using the same experimental data as in Table 2 and is given in Table 3. Analyzed in this way, the values were lower in the allantoamnionic membrane than in the placen-tome (p < 0.01) and intercotyledonary membrane (p < 0.005). It changed in the placentome (p < 0.005) and was highest in the second part of gestation. No changes were found in the intercotyledonary membrane and allantoam-nionic membrane.

TABLE 2. Amount of Ang II receptor in the bovine placenta and fetal membranes, related to the cell membrane protein (fmol/mg membrane protein) and given as median with range in parentheses.*

Tissue Day 1-95 (n = 7) Day 96-190 (n = 9) Day 191-290 (n = 7)
Placentome 185 465 100
Intercotyledonary membrane 2 750 945 260
Allantoamnionic membrane 1890 3430 1220

* n, Number of animals.

TABLE 3. Amount of Ang II receptor in the bovine placenta and fetal membranes, related to the wet tissue weight (fmol/g wet tissue) and given as median with range in parentheses.*

Tissue Day 1-95 (n = 7) Day 96-190 (n = 9) Day 191-290 (n = 7)
Placentome 1380 2390 1100
Intercotyledonary membrane 2000 1800 370
Allantoamnionic membrane 360 435 160

* n, Number of animals.

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