Antiphospholipid Antibodies: Materials

Antiphospholipid Antibodies: MaterialsSarcoidosis is a systemic disease of unknown cause characterized by the presence of non-caseating epithelioid cell granulomas in affected organs and shows a variety of clinical courses. It is well-known that patients with sarcoidosis have humoral immunologic abnormalities. Canadian helth& care mall Increases in serum immunoglobulin and complications of autoimmune diseases also have been reported. Some autoantibodies including antinuclear antibody, rheumatoid factor, and antilymphocyte antibody, also have been detected. However, the clinical significance of these antibodies now is the subject of considerable discussion.
Recently, serum antibodies against phospholipids (antiphospholipid antibodies, [aPL]) comprising cell membrane have been reported to be present in some autoimmune diseases and infectious diseases, and the presence of aPL has been shown to be associated with thromboembolic manifestations such as pulmonary embolism, cerebral infarction, and neurologic defects.
The purpose of this study is to detect aPL and to elucidate their relationship, if any, to the clinical manifestation of patients with sarcoidosis.
Fifty-five patients with sarcoidosis were studied for the presence of aPL. Sarcoidosis was diagnosed by the presence of epithelioid cell granulomas in organs on which biopsies were performed, including skin, lung, and lymph nodes, and on the basis of clinical features. Patients receiving steroid medication were excluded from this study due to possible inhibition of antibody production. There were 18 males and 37 females with an average age of 48.0 years old. The average duration since onset was five years. Four patients were in stage 0, 35 were in stage II, 13 in stage III, and 3 in stage IV according to the radiologic classification by Wurm et al.
This study was approved by the Institutional Committee on Human Research (Nagoya City University), and informed consent was obtained from all subjects.

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