Eligible subjects with CF were 18 years of age or older, English speaking, had confirmed diagnoses of CF on the basis of positive sweat tests, and were being actively followed by the Cystic Fibrosis Center at the University of California, San Diego (UCSD). Of 55 patients meeting these criteria, 37 agreed to participate. Consistent with the disproportionately high prevalence of CF among whites, all CF subjects were white.
Recruitment for the comparison group was conducted at local colleges and businesses. Comparison subjects were required to be between the ages of 18 and 45 years, to be free of chronic disease (as determined by self-report), to be nonsmokers (because of the assumption that few CF subjects would be smokers), and to be English speaking. Data from the 46 white subjects recruited into the comparison group form the basis for the analyses reported herein.
The study protocol was approved by the human subjects committees of UCSD and San Diego State University. All subjects provided informed consent. buy levaquin online
Instruments and Variables
Data were obtained by means of mailed questionnaires composed of closed-ended questions. For CF subjects a medical chart review was also conducted to obtain data on pulmonary function. Sociodemographic variables assessed included marital status, number of dependents, source of financial support, income, educational attainment, occupation, and employment status. Social class was assigned using the Hollingshead Two-Factor Index of Social Position, with some occupational status ratings adjusted up or down based on changes in status suggested by more recent ratings.